Skip to content


Your cart is empty

DermOne Skincare - Skin Perfecting Serum with Prebiotics. An oil-free serum that helps to protect against daily environmental stresses and impurities that can cause breakouts and redness. Botanicals help to reduce fine lines and wrinkles. Our next-generation all-natural solution contains our own patented Prebiotic Activ Technology plant-based prebiotic invented by our co-founder, Karen Sinclair Drake. We powered up this one-of-a-kind acne treatment serum with natural salicylic acid from the wintergreen plant. Why use benzoyl peroxide which causes, drying, itching and burning as reported by the FDA when you can use a natural product, that worked better and faster?

Clinically proven to work faster than the leading acne brand. Free from benzoyl peroxide. Our clean beauty products are vegan, cruelty-free, made with organic/natural ingredients, gluten-free and planet-friendly.

How to use

Use morning and night for best results on cleansed skin, keep away from the eye area.


1% Salicylic Acid* (from natural wintergreen extract) 1% acne medication. INACTIVE INGREDIENTS: Aqua (water), alcohol denat*†, glycerin*‡, salix nigra (black willow) bark extract, vaccinium myrtillus (bilberry) fruit extract, pinus nigra bud/needle extract*, ribes nigrum (blackcurrant) fruit extract*, salix alba (white willow) bark extract*, spiraea ulmaria (meadowsweet) flower extract‡, xanthan gum, saccharum officinarum (sugar cane) extract, aloe barbadensis (aloe) leaf juice*,levulinic acid§, citrus aurantium dulcis (orange) fruit extract, citrus limon (lemon) fruit extract, sodium levulinate§, acer saccharum (sugar maple) extract, potassium sorbate§, citric acid‡, sodium benzoate§

*Certified organic ingredients

†Made from organic sugar cane alcohol ‡From non-GMO, vegetable source §EU Cosmetics Directive approved preservatives considered to be the ‘natural alternatives for use in more natural-based personal care products. Prebiotic Activ Technology is a patented extract invented by co-founder, Karen Sinclair Drake.

Active Ingredient: Salicylic Acid 1%, purpose: acne medication.

Other Key Ingredients: glycerin, black willow bark extract, bilberry fruit extract, pine needle extract, blackcurrant fruit extract, white willow bark extract.


These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. Please note that any information provided is not intended to create any physician-patient relationship or supplant any in-person medical consultation or examination. Always seek the advice of a trained health professional with any questions you may have regarding a medical condition and before seeking any treatment. Proper medical attention and treatment should always be sought for specific ailments. Never disregard professional medical advice or delay in seeking medical treatment due to information obtained here.


Salicylic acid 1%:

derived from natural wintergreen extract. It is a potent astringent, anti-inflammatory and keratolytic agent that helps remove excess sebum, impurities and surface debris. Wintergreen acts as a numbing and pain-relieving agent similar to cortisone. It can ward off infections (bacterial, fungi and viral) and tone the skin and hair.

Aqua (water):

water in Latin, is the word used in the INCI (International Nomenclature of Cosmetic Ingredients) to label this vital element. Water is primarily used in practically all cosmetics and personal care products to dissolve many of the ingredients that impart skin benefits known as actives. It also forms emulsions where the oil and water components of the formula are combined to produce creams and lotions. These are referred to as oil-in-water emulsions, or as water-in-oil depending on the ratios of the oil and water phases.

Alcohol denat:

produced from the fermentation of organic plant sources (sugar). An effective extracting (solvent) medium for herbal extracts that takes out both water and oil-soluble nutrients. Can also be used as a natural preservative.


or glycerol, is released when an oil is hydrolysed, such as during soapmaking. A common cosmetic and food ingredient used as a natural humectant and moisturizer. Glycerin is one of the oldest and most respected skin moisturisers. It has been proven in many trials (both clinical and instrumental) to increase the moisture content of the skin and protect it from becoming dry and scaly. Glycerin is listed in all of the major pharmacopoeias and is used extensively for the treatment of the skin. Our glycerin is produced from GMO-free Karanja nut oil.

Salix nigra (black willow) bark extract:

a natural source of salicylic acid, a BHA with keratolytic, astringent and regenerative properties. It benefits acne-prone skin due to its pore-clearing, antiseptic, anti-microbial and anti-inflammatory nature.

Vaccinium myrtillus (bilberry) fruit extract:

contains vitamin C, resveratrol and bioflavonoids such as anthocyanins, quercitin and ellagic acid. Bilberries aid in the treatment of skin infections, ulcers, bruises and varicose veins. Their potent antioxidants protect the skin from the degenerative effects of free radicals as well as prevent the breakdown of collagen. They condition the skin and increase microcirculation including that of the eye area, thus reducing the appearance of fine lines and wrinkles.

Pinus nigra bud/needle extract:

provides prebiotic benefits that help mitigate P.acnes bacteria proliferation and combat the aging process. Contains methylsulfonylmethane (MSM) which detoxifies the skin and stimulates its regeneration.

Ribes nigrum (black currant) fruit extract:

chock-full of antioxidants, such as tannins and anthocyanins, that help reduce aging signs and prevent bacterial growth. Black currants have potent anti-inflammatory benefits as well as soften and nourish the skin.

Salix alba (white willow) bark extract:

a natural source of salicylic acid (salicin), a BHA with keratolytic, astringent and regenerative properties. It benefits acne-prone skin due to its pore-clearing, antiseptic and anti-inflammatory, anti-microbial nature. It also contains antioxidants (phenolic acids) which aid in skin rejuvenation.

Spiraea ulmaria (meadowsweet) flower extract:

has similar properties to slippery elm and willow bark due to its salicylic acid content. High in vitamin C and flavonoids, provides effective astringent, anti-inflammatory, cleansing, toning, tightening and soothing benefits.

Xanthan gum:

produced by bacteria through fermentation of non-GMO corn. This polyssacharide is used in food and cosmetic products as a thickener and stabilizer. Chosen for its natural and GMO-free source as we do not use acrylic (petrochemical sourced) thickeners or part synthetic. Xantham gums provides stability to gels and emulsions.

Saccharum officinarum (sugar cane) extract:

its natural glycolic acid concentration helps the epidermis shed dead skin cells easier and thereby prevent a build-up on its surface. This extract, furthermore, stimulates the production of collagen and elastin of the skin, which results in improved skin texture and smoothness.

Aloe barbadensis leaf juice freeze-dried powder:

has the ability to effectively penetrate and transport healthy substances through the skin. Aloe Vera provides numerous cutaneous skin benefits such as acting as an excellent moisturizer, keeping the skin flexible and supplying oxygen to cells, as well as increasing the strength and synthesis of skin tissue, thus preventing premature aging. Rich in mucopolysaccharides (naturally occurring sugars that keep the skin moist and plump), minerals, amino acids and enzymes, aloe has renowned soothing, anti-inflammatory and healing properties, making it suitable for cuts, grazes, insect bites, sunburn, acne, dermatitis, sensitive and irritated skin.

Levulinic acid:

classified in EU under skin conditioning and perfuming, but also having strong antimicrobial properties. Produced through the modification of non-GMO corn sugars with heat and acid. It is an effective, non-toxic and non-sensitizing preservative. It has no cosmetic restrictions placed on it and is permitted to use in organic formulations by organic certification bodies.

Citrus aurantium dulcis (orange) fruit extract:

rejuvenates the skin due to the action of its AHAs content. A concentrated source of vitamin C and flavonoids; orange nourishes, enriches and improves the skin’s elasticity while encouraging cellular activity and new cell growth. It helps reduce swollen tissue and stimulates the lymph system. Orange helps heal dry/irritated skin and it is extremely useful in treating broken capillaries and mild varicose veins (astringent). It has antiseptic and bactericide properties, therefore improving acne-prone skin.

Citrus limon (lemon) fruit extract:

tones and refreshes the skin, contains high levels of Vitamin C and AHAs which brighten the complexion. It has antibacterial, astringent and cell- regenerative properties. Lemon also helps heal dry, rough and chapped skin.

Sodium levulinate:

it is the sodium salt of levulinic acid, thus has similar properties. It is used as a EU approved preservative (inhibits microbial proliferation) and skin conditioning agent. It is derived from non GMO-corn.

Acer saccharum (sugar maple) extract:

like all sugars, it is an extraordinary humectant. Rich in trace minerals and zinc which balance oil production. It contains AHAs in their whole food format and antioxidants that keep premature aging at bay by exfoliating surface build-up as well as neutralizing the effect of environmental aggressors.

Potassium sorbate:

this is the potassium salt of sorbic acid. Our primary concern is the health and safety of those using our products. With that in mind, we must balance producing the most natural/organic product with producing a microbially safe and stable product. While sorbic acid is found in nature, it’s not yet produced from a plant source. For this reason it has been necessary in some of the products to add a synthetic antimicrobial. It’s a man-made preservative allowed in both food and cosmetics and permitted by organic certification bodies in cosmetics.

Citric acid:

an alpha hydroxy acid found naturally in citrus fruits. Used in our products at very low levels to regulate acidity to match the natural pH of the skin. Permitted food ingredient and by organic certification agencies; it is produced through bacterial fermentation of sugar.

Sodium benzoate:

is a synthetic preservative approved for use worldwide and is included on the European Union Cosmetics Directive “Positive List” (Europe has banned more than 1,200 ingredients due to safety concerns). It has also been approved by the Japanese Ministry of Health and Welfare in both rinse-off and leave-in applications. Japan, like Europe, abide by the most stringent criteria in the world concerning what ingredients can be used in personal care products to also keep the product itself free from harmful contamination. Europe´s comform level with the safety data associated with this permitted preservative is clearly reassuring.


G Tucker 

I had both acne and rosacea at the same time and this worked well at clearing my spotty red face up. The Doctor told me to continue using it which I did and to date I’ve had no new breakouts and its actually helped my skin to heal to where it now looks healthy and clear. I won’t be giving this up any time soon. G Tucker, Oija

Jon, CA 

I don’t even think of this as an acne medication because it looks like and feels like high-end skincare. My skin feels fresh and clean each time I use it.

Letitia, Indiana 

Best product I’ve ever used for clearing up acne fast and making my skin look healthier.

Justine TN 

My skin has cleared up very quickly since using this serum. I haven’t experienced any breakouts in a while. Just ordered the cleanser and mask. Can’t wait to try!

JC Maurey, Glendale 

I bought this specifically for the breakouts on my forehead and this Serum got rid of them! It’s been years since I’ve had such a clear, healthy-looking forehead. The rest of my face looks amazing too!

Sammy, Las Vegas 

This is great deluxe serum for treating active breakouts and texture, it definitely was able to tackle stubborn spots and prevent them from coming back. I’ve also noticed after about a week that zit scars have slightly faded making my complexion look brighter. I’m going to continue using to see how much clearer and brighter my face gets.

Trease, AZ 

It helps to keep my pores unclogged, I have had less breakouts and it made my skin tone more even. I love it and will buy it again.

Claudia R, Chatanooga 

I bought this for my partner to use to help prevent ingrowing hairs from shaving and to lighten up some areas of scarring and pigmentation. It has helped to smooth his skin and it’s not irritating. I’ve just ordered the Enzyme Cleanser and Mud Mask so he has a regime to use.

Enrique, Nevada 

As a guy who dealt with bad acne and breakouts in my teenage years which left many dark spots and scars, they follow me to this day. When my girlfriend discovered this it was a game changer. I put it on right after washing my face and it’s faded my dark/red spots and I haven’t had a zit since.

Sean T, Naples

As There can be a lot of BS in the world of skincare, but I love this brand for keeping their products affordable, irritant-free, and potent – i.e. the main ingredient that is advertised on the label is actually high on the ingredients list – like the prebiotics. I like to apply it on damp skin directly after cleansing to optimize the absorption of whichever serums/moisturizers follow. The change to my skin is apparent with every use – it makes my skin more even in terms of both texture and discoloration. This is one product in a pretty small list of must-haves in my kit!

Lauren, NC

As This did work for my acne breakouts, I just wish it had more of a perfume smell to it.

Jamillae Beverly Hills, FL

By far the best acne product I’ve ever used. I’ve tried and failed with lots. This cleared up my mild acne breakouts by the first week. Have kept using it daily so it doesn’t return. Have ordered the clear system.

Elija Feuntes

It’s not like using an acne treatment. I think this is a premium product. Would prefer it in a tube. Am happy with how my skin looks and feels.

M Folkeston / Verified Purchase 

My skin-savior! Got acne later in life (ugh!!) and didn’t want to feel like a teenager using benzoyl peroxide, so my derm turned me onto this product which uses prebiotic technology. I can feel it is better for skin and within a week, the acne was gone. I use daily to prevent any breakouts and layer with their Antioxidant Serum.

Derm 1™ Skin Perfecting Serum - Rosacea & Adult Acne Defense 1 fl oz
Derm 1™ Skin Perfecting Serum - Rosacea & Adult Acne Defense 1 fl oz Sale price$24.95