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A doctor’s favorite! Designed to be used morning and night for best results. Configured to last about 28 days for most. Contains our own all-natural exclusive patented Prebiotic Activ Technology™ extract, created by our co-founder, Karen Sinclair Drake Free from benzoyl peroxide (which has been known to cause drying itching or burning with some users)

STEP 1 – Multifruit Enzyme Cleanser with Prebiotics (1.69 fl oz / 50 ml)

STEP 2 – Skin Perfecting Serum with Prebiotics (1.014 fl oz / 30 ml)

STEP 3 – Skin Perfecting Blemish Corrector with Prebiotics (0.3 fl oz / 10 ml)

Click on each product link above to learn more.

Q: How long before I start seeing results?

The American Academy of Dermatology recommends sticking to acne treatment for up to 10 weeks because acne is one of the most difficult skin disorders to treat. So, be patient and persevere. Keep in mind during this process it is completely normal to experience a few extra breakouts as part of the die-off effect. If you do not notice any improvement after 10 weeks, please contact us for support.

Q: Can I use other products with these?

No, we recommend you discontinue other treatments as ingredients like benzoyl peroxide will interfere with the prebiotic action of this formula.


Shirleigh H 

I used to purchase PROACTIV for my acne, but after a few days my skin would get inflamed and flaky. My doctor recommended this system and at first I was really skeptical as they claim the prebiotics help control the acne-causing bacteria. I probably shouldn’t have doubted as much as I did because this actually did work. The cleanser really deep cleans my skin and doesn’t leave it feeling uncomfortable. The acne serum is quite luxurious (no smell) and goes straight into skin. Then for any pesky pimples I apply the blemish corrector and I have witnessed spots going overnight from this stuff. I’ve actually ordered just this for my son who gets the odd pimple and I know it’s something he will use because it doesn’t look like a medicated product which embarrasses him. Shirleigh H, Seattle

Alana V

My skin has been as clear as a bell since using this system. It took about 2 weeks to fully clear up my acne and even though my skin is now clear, I continue to use it because my skin simply loves the ingredients and I see how healthy it looks. Alana V, Chicago

Dr. Wendy Warner 

Ok, this is coming from someone who wears no makeup, doesn’t color her hair, and doesn’t even have any piercings: all of us need to take better care of our skin. Skincare products typically have a TON of nasty ingredients, the least of which is gluten. And yes, we absorb it all through our skin. I’ve found a line of products that are herbal-based, work really well, and are a reasonable cost. The creator of this line is a UK-based herbalist. I like these products so much that I decided to carry them at the office. There is one line for “older” skin (that would be me!) and one for acne-prone skin. Dr. Wendy Warner

Dr. Ron Hoffman 

I searched high and low for a healthy, effective, safe topical product for my patients until I stumbled across DermOne and SkinSanity; commercial acne products like those you see heavily advertised on TV and in magazines may provide relief from blemishes but their ingredients scare me. These clean products cleanse and disinfect skin with natural ingredients such as pine, black currant, meadowsweet, bilberry, lemon, orange, and willow bark. Dr. Ronald Hoffman

Derm 1™ Two Step Regimen
Derm 1™ Two Step Regimen Sale price$39.95